Posts by Yurii Aulchenko

Detecting variants shared between traits, detecting potential causality from GWAS summary data

Pickrell et al. (Pickrell et al., 2016) come up with a very nice approach which uses summary-level data to detect variants exhibiting effects on multiple traits. They also propose use of multi-locus information to infer causative relations between traits. The manuscript starts with reminding the reader that the observed association between a genetic variant and multiple […]

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Better eQTLs for integrative functional genomics? – discussion on SMR/HEIDI

This is a follow-up post to the mini-review of the work of Zhu et al. [1] and is a reaction to tweet from @JosephPowell_UQ 🙂 In short, in Zhu et al. [1] have used eQTL results from peripheral blood to answer the question of potential biological function affected by genetic variation associated with five complex trait. Using such eQTLs may […]

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Integration of summary data from GWAS and eQTL studies

In this work, Zhu and colleagues [1] start with asking the question whether it would be possible to use summary-level data coming from GWAS of a complex trait coupled with eQTL association results to address the question of causality. Could the association observed for the complex trait be explained by changes in the level of a […]

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, , Posted on 31 May 2016 by

Revised estimates for the number of human and bacteria cells in the body

With interest we read a review/analysis paper [1] which questions the ‘common knowledge’ that we have ten times more bacteria on/in us than we we have cells. The authors make an interesting historical analysis tracing the ’10:1′ statement back to its origins (back to the beginning of 1970s!); based on analysis of more recent literature, they […]

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