Posts by Yurii Aulchenko

, , , , , Posted on 27 November 2017 by

Massive open online course “From Disease to Genes and Back” is open

In PolyOmica, we some times need to train people in the basics of genetics and genomics. While training people in basics is fun, it is quite time consuming, and is not exactly our company’s core activity. For a long time, we thought that it would be great to have a massive open online course (MOOC) […]

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Detecting variants shared between traits, detecting potential causality from GWAS summary data

Pickrell et al. (Pickrell et al., 2016) come up with a very nice approach which uses summary-level data to detect variants exhibiting effects on multiple traits. They also propose use of multi-locus information to infer causative relations between traits. The manuscript starts with reminding the reader that the observed association between a genetic variant and multiple […]

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Better eQTLs for integrative functional genomics? – discussion on SMR/HEIDI

This is a follow-up post to the mini-review of the work of Zhu et al. [1] and is a reaction to tweet from @JosephPowell_UQ 🙂 In short, in Zhu et al. [1] have used eQTL results from peripheral blood to answer the question of potential biological function affected by genetic variation associated with five complex trait. Using such eQTLs may […]

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Integration of summary data from GWAS and eQTL studies

In this work, Zhu and colleagues [1] start with asking the question whether it would be possible to use summary-level data coming from GWAS of a complex trait coupled with eQTL association results to address the question of causality. Could the association observed for the complex trait be explained by changes in the level of a […]

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, , Posted on 31 May 2016 by

Revised estimates for the number of human and bacteria cells in the body

With interest we read a review/analysis paper [1] which questions the ‘common knowledge’ that we have ten times more bacteria on/in us than we we have cells. The authors make an interesting historical analysis tracing the ’10:1′ statement back to its origins (back to the beginning of 1970s!); based on analysis of more recent literature, they […]

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