Tag: MultiOmics

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Understanding genetic control of human protein N-glycosylation

Glycosylation – addition of carbohydrates – is a common cotranslational and posttranslational modification of proteins. Attachment of different glycans to the same protein can give rise to hundreds of its glycoforms. Different glycosylation of the same glycoprotein changes its physical properties as well as its biological function. In recent years, changes in different glycan abundances were associated with various diseases, including many of these […]

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https://www.mimomicsucam.com/

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Teaching at the Research MIMOmics Summer School in Cambridge (UK)

From 20 till 27 August, the EU FP7 consortium MIMOmics in which PolyOmica is a partner, organises a Summer School including a Workshop in Omics Studies. The goal of the School is to train a new generation of statistical omics scientists with a biological and biotechnological background to enable them to understand and to apply […]

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Detecting variants shared between traits, detecting potential causality from GWAS summary data

Pickrell et al. (Pickrell et al., 2016) come up with a very nice approach which uses summary-level data to detect variants exhibiting effects on multiple traits. They also propose use of multi-locus information to infer causative relations between traits. The manuscript starts with reminding the reader that the observed association between a genetic variant and multiple […]

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Better eQTLs for integrative functional genomics? – discussion on SMR/HEIDI

This is a follow-up post to the mini-review of the work of Zhu et al. [1] and is a reaction to tweet from @JosephPowell_UQ 🙂 In short, in Zhu et al. [1] have used eQTL results from peripheral blood to answer the question of potential biological function affected by genetic variation associated with five complex trait. Using such eQTLs may […]

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