Tag: glycomics

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Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases

Immunoglobulin G (IgG) that plays central role in adaptive immunity is the most abundant immunoglobulin found in human plasma. All IgG molecules are N-glycosylated. N-glycosylation of IgG contributes to the maintenance of its structure, stability, and solubility. In a large collaborative study, we analysed association between genomes and glycosylation of immunoglobulin G (IgG) in more than […]

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Understanding genetic control of human protein N-glycosylation

Glycosylation – addition of carbohydrates – is a common cotranslational and posttranslational modification of proteins. Attachment of different glycans to the same protein can give rise to hundreds of its glycoforms. Different glycosylation of the same glycoprotein changes its physical properties as well as its biological function. In recent years, changes in different glycan abundances were associated with various diseases, including many of these […]

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Chronic inflammation and low back pain

Last Thursday, July 5, 2018, a manuscript1 reporting results from a large multicentric case-control study of patients with chronic lower back pain (CLBP) was published in Biochimica et Biophysica Acta (BBA) – General Subjects. The work was funded by the EU FP7 project PainOmics in which we participate. The study of plasma N-glycome composition in patients […]

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