Tag: ComplexTraits

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Identification of sixty three multigenic modules involved in susceptibility to inflammatory bowel disease

Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and small intestine. Crohn’s disease (CD) and ulcerative colitis (UC) are the principal types of inflammatory bowel disease.  IBD was virtually unheard of in the early nineteen hundreds. Since then it’s incidence (as well as that of a series of other inflammatory diseases including asthma) has dramatically […]

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The Erasmus bridge in Rotterdam, NL

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Teaching at the “Advances in GWAS” course in Rotterdam next week

Next week (starting Monday January 30 2017) Yurii and I will be in Rotterdam at the Erasmus University Medical Center where we will teach in the “Advances in Genome-Wide Associations” course of NIHES. This course is part of the Master’s programme in Health Sciences and is compulsory for those who follow the specialisation “Genetic Epidemiology”. […]

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Detecting variants shared between traits, detecting potential causality from GWAS summary data

Pickrell et al. (Pickrell et al., 2016) come up with a very nice approach which uses summary-level data to detect variants exhibiting effects on multiple traits. They also propose use of multi-locus information to infer causative relations between traits. The manuscript starts with reminding the reader that the observed association between a genetic variant and multiple […]

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Better eQTLs for integrative functional genomics? – discussion on SMR/HEIDI

This is a follow-up post to the mini-review of the work of Zhu et al. [1] and is a reaction to tweet from @JosephPowell_UQ 🙂 In short, in Zhu et al. [1] have used eQTL results from peripheral blood to answer the question of potential biological function affected by genetic variation associated with five complex trait. Using such eQTLs may […]

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